Best Luxury Accessible Mediterranean Cruises
By John Sage
Treat yourself to a relaxing luxury accessible Mediterranean cruise! Travelers looking for first class amenities will love being aboard the Crystal Serenity cruise ship.
Home to some of the best cuisine you will find anywhere (think celebrity chefs and Michelin stars), sommeliers offering exquisite wines, and world-class service, Crystal Cruises regularly receives the top travel industry awards.
An accessible Mediterranean luxury cruise is the perfect way to visit some of the world’s greatest cities such as Venice, Rome, Barcelona, and Istanbul without having to compromise on comfort and conveniences. We also offer accessible cruise excursions in nearly every port you will visit, so your vacation will undoubtedly be a memorable one!
Crystal’s 12 night accessible luxury Mediterranean cruise starts in Venice, ends in Barcelona, and visits 6 amazing, accessible ports in between! You will see the best both worlds: world-famous tourist sights in cities like Venice, Florence, Barcelona, Monte Carlo, and Rome as well as small-town charm and gorgeous scenery in Kotor (Montenegro), Taormina (Sicily), and Sorrento (Naples). Accessible cruise excursions are available in most of the ports you will be visiting so you will have several opportunities to explore as well as relax!
- Venice (2 Days) – You’ll have an overnight stay onboard the ship in Venice. Since jet lag can often occur on the first day, many people opt for a 1 to 3 night hotel stay before their cruise. With a few days in Venice, you can leave behind the tourist crowds in St. Mark’s square and explore the charming small streets and canals that many visitors miss. You can also take accessible boat rides to the islands of Burano and Murano to see an entirely different side of the Venetian Islands!
- Kotor (Montenegro) – This UNESCO World Heritage Site offers numerous small streets and squares to visit in this medieval walled town. The famous Cathedral of St. Triphon, a scenic drive along Lovcen Mountain, and various baroque buildings all make for great photo opportunities.
- Taormina (Sicily) – The charming town of Taormina has been a getaway for European nobility since Emperor Wilhelm II in the 1800’s. The Roman Theatre, the Roman Odeon, and the Fortress Cathedral are a few of the sightseeing opportunities in Taormina. Booking accessible tours to Messina, Syracuse, and Mount Etna are also possible.
- Sorrento (Naples) – The small town of Sorrento perched on Italian cliffs offers scenic views of the Bay of Naples below. Accessible excursions are also available to the Amalfi Coast, Mt Vesuvius, the ruins of Pompeii and Herculaneum, and the idyllic island of Capri.
- Civitavecchia (Rome) – If this is your first or second time in Rome, you will likely want to concentrate on the highlights: the Sistine Chapel, St. Peter’s Basilica, the Colosseum, the Roman Forum, Piazza Navona, Campo de Fiori, the Spanish Steps, and the Trevi Fountain. Repeat visitors will be able to spend their time visiting other worthwhile sites like the excavations at the ancient Roman port of Ostia Antica, historical artifacts in the National Museum of Rome, the Church of the Gesù, and more.
- Monte Carlo (2 Days) – With two days in Monte Carlo, you’ll be able to spend ample time in both Monte Carlo and in Nice, France. Monte Carlo’s Grand Casino, Oceanographic Museum, and royal sights including the tomb of Princess Grace Kelly are just a few of the attractions near your ship. Accessible transportation can be booked to further sights such as Eze-le-Village, Nice, Antibes, and Cannes.
- Livorno (Florence/Pisa) – Most cruise passengers stopping in Livorno head straight to Florence to visit the incredible Renaissance attractions including Michelangelo’s David, the Duomo Cathedral, the tombs of Michelangelo and Galileo inside the Santa Croce church, and the Uffizi Gallery masterpieces.
- Barcelona (2 Days) – The perfect ending to your accessible luxury Mediterranean cruise is an overnight stay in Barcelona, which will allow you to spend time at a wheelchair accessible beach or sightsee inside the city. Underground accessible Roman ruins, the Picasso Museum, the gothic architecture of the Barcelona Cathedral, and the famous Las Ramblas boulevard are a few of the sights to visit here. Be sure you don’t miss Guadi’s Sagrada Familia church…not that you could because it towers over the city!
Like the Crystal Cruise mentioned above, this luxury accessible Mediterranean cruise offers a variety of accessible shore excursion options. It also offers the same luxury amenities aboard the Crystal Serenity including all-suite staterooms, Egyptian cotton bath towels, expert wine consultants, chic boutiques, and concierge service.
This 7-Night Crystal Cruise itinerary visits Barcelona (2 days), Cannes, Livorno (Florence/Pisa), Portofino, and Monte Carlo (2 days). Barcelona and Livorno shore excursion options are described above on the 12-Night Grand Mediterranean Cruise. In Cannes, you will have similar options as the Nice excursions described in Accessible Vacation #23.
In Portofino and Monte Carlo, you will get to experience the lavish lifestyle that these jetsetter destinations offer. Portofino is a beautiful town surrounding a hidden harbor. You can spend the day shopping and dining in town, or hire a tour guide to show you nearby Santa Margherita Ligure and Genoa. Monte Carlo’s Grand Casino opens each afternoon and has a strict dress code…James Bond and other celebrities have frequented here for decades. Jacques Cousteau’s Oceanographic Museum, the Royal Palace, and the final resting place of Princess Grace Kelly are all worth visiting while here.
The Crystal Serenity cruise ship offers a luxurious 7 night cruise from Venice to Istanbul and includes extended stays in both cities.
- Venice (2 Days) – Described in Accessible Vacation #45.
- Dubrovnik – The most visited city in Croatia offers a medieval walled city and great photo opportunities including the Onofrio Fountain, the Franciscan Monastery, and the 15th century Rectors’ Palace.
- Mykonos – The famous 4 windmills and the Little Venice seafront greet cruise passengers arriving in Mykonos. During your shore excursion, you can visit the winding streets and harbor front in Mykonos town or spend some time in the sun on one of the picturesque beaches.
- Kusadasi – Kusadasi is the gateway port to Ephesus, home to ruins of one of the most significant Roman cities during early Christian times. Paul wrote his Letter to the Ephesians to the residents here, and you can still see the theatre, amphitheatre, and famous Library of Celcus.
- Istanbul (2 Days) – Formerly known as Constantinople, Istanbul has been one of the great centers of Western Civilization for the last 2500 years. You’ll need two days to catch some of the highlights: one day to visit the Blue Mosque, Hagia Sophia, and sprawling Topkapi Palace, and another day to visit the Grand Bazaar, the often-overlooked National Archaeological Museum, the Spice Market, and the underground Basilica Cistern.
The 19-Night Crystal Cruise from Venice to Rome is the best luxury accessible Mediterranean Cruise that exists. It features accessible excursions in 12 out of the 13 ports. I especially like that this cruise includes extended visits to some great locations including an overnight stay in Venice, two visits to the island of Mykonos, and three days in Istanbul!
Ports of Call on this cruise include Venice (2 Days), Dubrovnik, Mykonos, Kusadasi (Ephesus), Istanbul (3 Days), Kusadasi (Ephesus), Mykonos, Santorini, Monemvasia, Valletta, Taormina, Sorrento, and Civitavecchia (Rome). All of these ports are described in the cruises listed above except Monemvasia and Santorini.
Monemvasia’s ancient city walls and many Byzantine churches exhibit the rich history of this tiny Greek town. The medieval fortifications and the man-made causeway linking Monemvasia to the mainland bear testimony to its strategic importance over the centuries.
Santorini is widely considered to be the most scenic of the Greek Islands. The massive volcanic eruption 3600 years ago left a caldera 12 km by 7 km wide and may be the basis for the story of Atlantis. When you visit Santorini, you’ll be able to see some of the most well known views in the Mediterranean including the famous blue-domed churches in Oia.
#50 – Your Custom Accessible Vacation
We have a wealth of accessibility knowledge on destinations throughout Europe. We can customize a vacation for you based on your own preferences. Contact us with your desired itinerary, dates, and traveler details, and we’ll customize a trip for you!
Learn more about the Top 50 Awesome Accessible European Vacations:
1-6: London & Paris
7-11: The Low Countries (Belgium, the Netherlands, Denmark, and more)
12-14: Baltic Cruises
23-25: Mediterranean Riviera
26-27: Ancient Civilizations
28-31: Europe-wide Vacations
32-34: Mediterranean Cruises from Barcelona
35-38: Mediterranean Cruises from Rome and Istanbul
39-43: Mediterranean Cruises from Venice
44-45: 3 to 4 Week Mediterranean Cruises
46-50: Luxury Mediterranean Cruises